Primary diffuse large B-cell lymphoma or lymphomatoid granulomatosis grade 3: \ud a still-puzzling diagnosis in autopsy

摘要

Primary lung lymphoma is a rare entity accounting for approximately 0.3% of\udall primary neoplasia of the lung and includes diffuse large B-cell lymphoma\ud(DLBL) and lymphomatoid granulomatosis (LYG). Considering that clinical\udfeatures may be similar, whereas epidemiology, morphology, and radiological\udfeatures are different, the authors report a case of a middle-aged man\udwho presented multiple pulmonary nodules in the lower lobes and groundglass\udopacities scattered bilaterally on computed tomography. Clinically, he\udpresented a consumptive syndrome with respiratory failure and pleurisy,\udwhich progressed until death. The autopsy findings were consistent with\udlymphomatoid granulomatosis (LYG) grade 3/ diffuse large B-cell lymphoma\ud(DLBL). The authors call attention to the difficulty of establishing an accurate\uddiagnosis, mainly when the demonstration of EBV-infected atypical B-cells\udfails.